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Host Polymorphisms May Impact SARS-CoV-2 Infectivity.
Brest, Patrick; Refae, Sadal; Mograbi, Baharia; Hofman, Paul; Milano, Gerard.
Trends Genet ; 36(11): 813-815, 2020 11.
Article in English | MEDLINE | ID: covidwho-704022

ABSTRACT

Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.


Subject(s)
ADAM17 Protein/genetics , Betacoronavirus/physiology , Coronavirus Infections/genetics , Peptidyl-Dipeptidase A/genetics , Pneumonia, Viral/genetics , Polymorphism, Genetic/genetics , Serine Endopeptidases/genetics , ADAM17 Protein/metabolism , Angiotensin-Converting Enzyme 2 , COVID-19 , Coronavirus Infections/virology , Disease Susceptibility , Humans , Pandemics , Peptidyl-Dipeptidase A/metabolism , Pneumonia, Viral/virology , Polymorphism, Single Nucleotide/genetics , Promoter Regions, Genetic/genetics , SARS-CoV-2 , Serine Endopeptidases/metabolism , Virus Internalization , Virus Shedding
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